The Strokes and Swedish House Mafia head up the In New Music We Trust stage at Radio 1's Big Weekend 2011, which takes place in Carlisle 14-15 May.
Other acts set to appear include Friendly Fires, Nero and Noah and the Whale as well as The Vaccines, Wretch 32, Magnetic Man and Two Door Cinema Club.
They join a bill that boasts Foo Fighters and Lady Gaga as well as My Chemical Romance, The Black Eyed Peas, Tinie Tempah, Chase And Status, Plan B, Ellie Goulding, Jessie J and more.
More names are expected to be announced in the coming weeks for the BBC Introducing stage and Outdoor Arena.
20,000 music lovers are expected to attend the event will take over Carlisle in Cumbria with four stages of live music.
Radio 1’s One Big Weekend 2011 tickets are to be handed out for free with the majority going to residents of Carlisle and other local areas.