Datarock, The Whip and An Experiment On A Bird In The Air Pump are among the first names confirmed for Camden Crawl.
The Author, Baddies, The Barker Band, Bleech, BLK JKS, Brakes and The Chapman Family have also been announced alongside Chew Lips, The Computers and The Cordelier Club.
Virtual Festivals' pick of 2009 Dan Black, Danny And The Champions Of The World, The Dead Formats, De Tropix, Die! Die! Die! and Drums Of Death will also appear.
Other names confirmed include Elvin, Fight Like Apes, Flashguns, Foy Vance, General Fiasco, Goldheart Assembly, Golden Silvers, Goldielocks, Heartbreak, Hexes, I Blame Coco and It Hugs Back.
Elsewhere James Yuill, The Jim Jones Revue, Josh Weller, The Joy Formidable, Kasms, The King Blues, Lion Club, Little Death, Man Like Me, Marina And The Diamonds and Newham Generals will all appear.
Patrick Wolf, Peggy Sue, Pulled Apart Bu Horses, S.C.U.M., Skint And Demoralised, Sleepercurve, The Temper Trap, Threatmantics, Three Trapped Tigers, Toddla T, Tommy Sparks, The Von Blondies, VV Brown and The XX have also been added to the bill.
Camden Crawl 2009 will take place at various venues around Camden, north London from 24-25 April.
Tickets are on sale now at £55 for two days or £32.50 for just one. The festival wristband will give festival-goers entry to all venues, subject to capacity.
Away from the music, organisers are promising poetry, magic, street theatre, comedy, arts and crafts and daytime gigs to compliment the evening's entertainment.