Blondie, Los Lobos and Imelda May are to join headliners Van Morrison and Bob Dylan as the newest additions to the festival.
Joining them will be Damien Dempsey, Afro Celt Sound System, Richard Thompson, Peter Green And Friends and Sweet Billy Pilgrim (2 July).
Devendra Banhart, Tuung, The Jim Jones Revue, Pete Molinari and Jon Allen have also been added to the line-up for Saturday (3 July).
The latest additions join the existing impressive line-up which will see Bob Dylan performing a UK festival exclusive as he headlines the Saturday.
Other artists already confirmed include Ray Davies, The Magic Numbers, Mumford And Sons, The Magic Numbers, Seasick Steve, Peter Doherty and Laura Marling.
The event, which lies in unspoilt countryside, is set to return to festivals of old with organisers refusing to have any sponsorship, VIP areas or ticket registration schemes.
Tickets are on sale now priced at £110 and two-night camping is available for an additional £25. Friday tickets are priced at £45 and Saturday tickets are £65.
Click here to buy Hop Farm Festival tickets.
Hop Farm 2010 will take place in The Hop Farm, Kent from 2-3 August.